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Sentinel node biopsy in oral squamous cell carcinoma.
Francisco Civantos1, Robert Zitsch, Anthony Bared
1Department of Head & Neck, University of Miami, Miami, FL 33136, USA. f.civantos@miami.edu
Journal of Surgical Oncology
|September 20, 2007
Summary
Sentinel node biopsy shows promise for early oral cancers, excluding floor of mouth tumors. This technique, when validated, could aid in managing oral cancer by identifying metastasis.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Sentinel node biopsy (SNB) is established for cutaneous melanoma.
- Its application is being explored for other solid tumors, including oral cavity cancers.
Purpose of the Study:
- To assess the utility and accuracy of SNB for early oral cancers.
- To evaluate SNB's effectiveness in identifying nodal metastasis in the oral cavity.
Main Methods:
- A multi-institutional pathologic validation trial was conducted.
- Sentinel node biopsy was followed by completion selective neck dissection.
- Routine pathologic techniques were used for initial analysis.
Main Results:
- Preliminary data suggest SNB is useful for early oral cancers, except floor of mouth tumors due to technical challenges.
- Routine pathologic techniques yielded a 96% negative predictive value for oral cancers (excluding floor of mouth).
Conclusions:
- Sentinel node biopsy demonstrates potential for managing early oral cancer.
- Further clinical trials with follow-up are necessary to confirm efficacy and recurrence rates.
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