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Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...

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Related Experiment Video

Updated: Jul 11, 2026

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
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The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Clindamycin-induced acute cholestatic hepatitis.

Cem Aygun1, Orhan Kocaman, Yesim Gurbuz

  • 1Department of Gastroenterology, Kocaeli University Medical Faculty, Kocaeli 41380, Turkey. caygun1@yahoo.com

World Journal of Gastroenterology
|September 20, 2007
PubMed
Summary

Clindamycin can cause acute liver injury (hepatotoxicity) in some patients, presenting as jaundice and elevated liver enzymes. Prompt drug discontinuation is crucial for potential recovery from this drug-induced hepatitis.

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The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
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Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Infectious Diseases

Background:

  • Clindamycin is a widely used antibiotic for various infections.
  • Drug-induced liver injury (DILI) is a significant concern in clinical practice.
  • Dental infections are common indications for clindamycin use.

Observation:

  • A 42-year-old woman developed acute hepatotoxicity after 6 days of clindamycin for a dental infection.
  • Symptoms included fatigue, nausea, vomiting, anorexia, pruritus, and jaundice.
  • Laboratory tests revealed significantly elevated liver enzymes (ALT, AST, ALP, GGT) and bilirubin levels.

Findings:

  • Liver biopsy confirmed mixed-type (hepatocellular and cholestatic) hepatic injury.
  • The Naranjo probability scale indicated clindamycin as the probable cause of drug-induced hepatitis.
  • Discontinuation of clindamycin led to hospitalization and subsequent recovery.

Implications:

  • Clindamycin poses a risk of acute mixed-type liver toxicity in susceptible individuals.
  • Early recognition and drug cessation are crucial for preventing severe liver injury.
  • This case highlights the importance of monitoring liver function during clindamycin therapy.