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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jul 11, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Resistance training and bone mineral density during growth.

M Z Smith1, B M Goettsch, R D Van Ramshorst

  • 1Department of Biological Sciences, Chapman University, Orange, CA 92866, USA.

International Journal of Sports Medicine
|September 21, 2007
PubMed
Summary

Heavier weight, fewer repetitions resistance training significantly increased bone mineral density in rats. Lighter weight, more repetitions also boosted bone modeling markers but not bone density.

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Area of Science:

  • Exercise Physiology
  • Bone Biology
  • Biomechanical Engineering

Background:

  • Resistance training is crucial for skeletal health.
  • Understanding optimal training parameters for bone development is essential.
  • Bone modeling and bone mineral density (BMD) are key indicators of skeletal maturity and strength.

Purpose of the Study:

  • To compare the effects of high-intensity (HI) versus low-intensity (LI) resistance training on bone modeling and BMD in maturating rats.
  • To determine if equivalent training volumes of different intensities yield similar bone adaptation.
  • To investigate the osteogenic response to distinct resistance training protocols.

Main Methods:

  • Twenty-three male rats were divided into control, LI, and HI groups.
  • LI and HI groups underwent 6 weeks of vertical ladder climbing with appended weights.
  • Training protocols were designed with equivalent total work volumes but different weight/repetition schemes.

Main Results:

  • Serum osteocalcin (OC), a bone formation marker, was significantly elevated in both HI and LI groups compared to controls.
  • High-intensity (HI) resistance training led to a significant increase in tibial bone mineral density (BMD) compared to both LI and control groups.
  • Low-intensity (LI) training did not result in a significant difference in BMD compared to the control group.

Conclusions:

  • Both high-intensity (HI) and low-intensity (LI) resistance training stimulate bone modeling, as indicated by increased serum osteocalcin.
  • Only high-intensity (HI) resistance training, characterized by heavier weights and fewer repetitions, significantly enhances bone mineral density in maturating rats.
  • Training intensity, not just volume, plays a critical role in achieving significant bone mineral density gains through resistance exercise.