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Heat acclimation and HSP-72 expression in exercising humans.

A M Watkins1, D J Cheek, A E Harvey

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This summary is machine-generated.

A 7-day heat acclimation protocol improved physiological markers of heat tolerance but did not alter heat shock protein 72 (HSP-72) expression in human skeletal muscle.

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Area of Science:

  • Exercise Physiology
  • Molecular Biology
  • Environmental Medicine

Background:

  • Heat acclimation enhances thermotolerance.
  • Heat shock proteins (HSP-72) are cellular markers of stress.
  • The relationship between physiological adaptation and HSP-72 expression during heat acclimation is not fully understood.

Purpose of the Study:

  • To investigate the effect of a 7-day heat acclimation protocol on HSP-72 expression in human skeletal muscle.
  • To examine the relationship between molecular and physiological markers of heat acclimation.

Main Methods:

  • Ten recreationally active males underwent a 7-day heat acclimation protocol (cycling at 75% VO2peak in 39.5°C, 27% RH).
  • Muscle biopsies were collected on days 1 and 7 (pre-, 6h post-, 24h post-exercise) to measure HSP-72 protein.
  • Physiological markers including core temperature, heart rate, oxygen uptake, sweat rate, and plasma cortisol were measured.

Main Results:

  • Significant reductions in core temperature, heart rate, and plasma cortisol were observed on day 7 compared to day 1, indicating physiological heat acclimation.
  • No significant differences in VO2, intramuscular temperature, skin temperature, or sweat rate were found between days 1 and 7.
  • HSP-72 protein expression in skeletal muscle showed no significant changes following the 7-day heat acclimation protocol.

Conclusions:

  • The 7-day heat acclimation protocol effectively induced physiological adaptations for heat tolerance.
  • Despite physiological improvements, HSP-72 expression in skeletal muscle did not increase, suggesting it may not be a primary molecular indicator of heat acclimation in this context.