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Related Experiment Videos

Squamous cell apocrine hidradenoma.

Jorge Angulo1, Gerardo Jaqueti, Heinz Kutzner

  • 1Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Avenida Reyes Católicos 2, 28040-Madrid, Spain.

Journal of Cutaneous Pathology
|September 21, 2007
PubMed
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This study describes two rare cases of apocrine hidradenoma, a benign skin tumor, predominantly composed of squamous cells. The findings suggest renaming this variant "squamous cell apocrine hidradenoma" for better classification.

Area of Science:

  • Dermatopathology
  • Oncology
  • Histology

Background:

  • Apocrine hidradenoma is a benign neoplasm originating from apocrine glands.
  • Typically, these tumors exhibit differentiation towards apocrine cells, often clear or polygonal.
  • Variations in cell composition are common, but squamous cell predominance is rare.

Observation:

  • Two cases of apocrine hidradenoma with a predominant squamous cell component were analyzed.
  • Histopathology revealed solid and cystic areas with basaloid polygonal cells peripherally and squamous cells forming the bulk.
  • Decapitation secretion was observed in tubular structures, and the stroma was sclerotic.

Findings:

  • The neoplastic cells primarily exhibited squamous differentiation, characterized by eosinophilic cytoplasm and vesicular nuclei.

Related Experiment Videos

  • Foci of mucinous cells were noted in one case, particularly around ductal structures.
  • The stroma showed sclerosis, and the neoplasms were demarcated by artefactual clefts.

    • Implications:

    • The distinct squamous morphology in these cases warrants specific classification.
    • The proposed term "squamous cell apocrine hidradenoma" accurately reflects the histopathologic findings.
    • This classification aids in differentiating these rare variants from typical apocrine hidradenomas.