Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...

Antibody Structure

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Beyond decentralized compliance: a call for a central regulatory office for AI in healthcare.

Virchows Archiv : an international journal of pathology·2025

Same author

Application and internal validation of lung ultrasound score in COVID-19 setting: The ECOVITA observational study.

Pulmonology·2024

Same author

Influence of allergic status and nasal polyposis on long-term Benralizumab response in eosinophilic severe asthma.

La Clinica terapeutica·2023

Same author

Severe asthma and long-term Benralizumab effectiveness in real-life.

European review for medical and pharmacological sciences·2022

Same author

C-reactive protein but not procalcitonin may predict antibiotic response and outcome in infections following major abdominal surgery.

Updates in surgery·2021

Same author

Clinical application of lung ultrasound score on COVID-19 setting: a regional experience in Southern Italy.

European review for medical and pharmacological sciences·2021

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Anti-chemokine therapy for inflammatory diseases.

M L Castellani¹, K Bhattacharya, M Tagen

¹Department of Internal Medicine and Science of Ageing, University of Chieti, Italy. mlcastellani@unich.it

International Journal of Immunopathology and Pharmacology

|September 21, 2007

Summary

This summary is machine-generated.

Chemokines like CCL2/MCP-1 and CCL5/RANTES are key in inflammation. Inhibiting these chemokines shows promise for treating various diseases, including cancer and autoimmune disorders.

More Related Videos

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

Published on: September 15, 2023

Related Experiment Videos

Last Updated: Jul 11, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

Published on: September 15, 2023

Area of Science:

Immunology
Molecular Biology
Cell Biology

Background:

Chemokines are inflammatory proteins that signal through G-protein coupled receptors.
CCL2/MCP-1 and CCL5/RANTES are key CC chemokine subfamily members involved in inflammation.
These chemokines regulate inflammatory cell recruitment to tissues.

Purpose of the Study:

To explore the emerging roles of RANTES and MCP-1 in inflammation.
To investigate the therapeutic potential of inhibiting MCP-1 and RANTES.
To assess the utility of RANTES and MCP-1 as diagnostic and prognostic markers.

Main Methods:

Review of chemokine signaling pathways.
Analysis of the role of CC chemokines in inflammatory cell recruitment.
Evaluation of therapeutic strategies targeting MCP-1 and RANTES.

Main Results:

MCP-1 and RANTES play significant roles in inflammatory cell recruitment.
Inhibition of MCP-1 and RANTES demonstrates potential therapeutic benefits.
These chemokines may serve as valuable diagnostic and prognostic indicators.

Conclusions:

CCL2/MCP-1 and CCL5/RANTES are critical in inflammatory processes.
Targeting these chemokines offers therapeutic avenues for diverse diseases.
RANTES and MCP-1 hold potential for diagnostics and prognostics in various clinical conditions.