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Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
Anti-chemokine therapy for inflammatory diseases
M L Castellani1, K Bhattacharya, M Tagen
1Department of Internal Medicine and Science of Ageing, University of Chieti, Italy. mlcastellani@unich.it
International Journal of Immunopathology and Pharmacology
|September 21, 2007
Summary
Chemokines like CCL2/MCP-1 and CCL5/RANTES are key in inflammation. Inhibiting these chemokines shows promise for treating various diseases, including cancer and autoimmune disorders.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- Chemokines are inflammatory proteins that signal through G-protein coupled receptors.
- CCL2/MCP-1 and CCL5/RANTES are key CC chemokine subfamily members involved in inflammation.
- These chemokines regulate inflammatory cell recruitment to tissues.
Purpose of the Study:
- To explore the emerging roles of RANTES and MCP-1 in inflammation.
- To investigate the therapeutic potential of inhibiting MCP-1 and RANTES.
- To assess the utility of RANTES and MCP-1 as diagnostic and prognostic markers.
Main Methods:
- Review of chemokine signaling pathways.
- Analysis of the role of CC chemokines in inflammatory cell recruitment.
- Evaluation of therapeutic strategies targeting MCP-1 and RANTES.
Main Results:
- MCP-1 and RANTES play significant roles in inflammatory cell recruitment.
- Inhibition of MCP-1 and RANTES demonstrates potential therapeutic benefits.
- These chemokines may serve as valuable diagnostic and prognostic indicators.
Conclusions:
- CCL2/MCP-1 and CCL5/RANTES are critical in inflammatory processes.
- Targeting these chemokines offers therapeutic avenues for diverse diseases.
- RANTES and MCP-1 hold potential for diagnostics and prognostics in various clinical conditions.
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