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Updated: Jul 11, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

[Growth hormone administration in the treatment of growth retardation in juvenile SLE--case history]

Anna Górska1, Maria Gardziejczyk, Mirosława Urban

  • 1II Klinika Chorób Dzieci Dzieciecego Szpitala Klinicznego AM w Białymstoku. agorska50@wp.pl

Pediatric Endocrinology, Diabetes, and Metabolism
|September 21, 2007
PubMed

Insights

Growth hormone (GH) therapy effectively promoted catch-up growth in a young patient with juvenile systemic lupus erythematosus (JSLE). The one-year treatment resulted in significant height increase with no major adverse effects.

Area of Science:

  • Pediatric Endocrinology
  • Autoimmune Diseases
  • Growth Disorders

Background:

  • Juvenile systemic lupus erythematosus (JSLE) can cause chronic inflammation and growth inhibition, often exacerbated by long-term steroid therapy.
  • Assessing the efficacy of growth hormone (GH) therapy is crucial for managing growth deficits in children with chronic illnesses.

Observation:

  • A 17-year-old female with JSLE, diagnosed at age 11, experienced significant growth failure (148 cm at 16 years old, below the 3rd percentile).
  • Prior to GH therapy, her growth rate had slowed to approximately 1 cm/year, with a skeletal age of 11 years.
  • She presented with Tanner stage II thelarche and Tanner stage I pubarche, indicating delayed puberty.

Findings:

  • One year of GH therapy (30 IU weekly) resulted in a 7.5 cm height increase within the first six months, reaching 161 cm.
  • The treatment period was characterized by disease stability, with no JSLE exacerbations or glucose intolerance.
  • Minor side effects included transient thirst and lower extremity edema in the first week, with overall improved well-being.

Implications:

  • GH therapy can facilitate catch-up growth in adolescents with JSLE, counteracting disease-related and treatment-induced growth impairment.
  • This approach appears safe and effective, leading to significant height gain without compromising disease control or causing serious adverse events.
  • Further research into long-term outcomes and optimal dosing strategies for GH therapy in JSLE patients is warranted.
Abstract

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