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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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The urethra is a hollowed tubular organ through which urine is expelled from the body. This structure extends from the bladder to the external opening, allowing urine to be released.
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Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
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Preliminary findings with the Solyx single-incision sling system in female stress urinary incontinence.

International urogynecology journal·2009
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Effectiveness and tolerability of extended-release oxybutynin vs extended-release tolterodine in women with or without prior anticholinergic treatment for overactive bladder.

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A Novel Surgical Technique in a Sheep Model for Suburethral Graft Implantation
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Thoughts on midurethral synthetic slings.

Scott Serels1

  • 1Bladder Control Center of Norwalk, Section of Urogynecology, Norwalk Hospital, 12 Elmcrest Terrace, Norwalk, CT 06880, USA. scottserels@hotmail.com

Current Urology Reports
|September 21, 2007
PubMed
Summary

Stress urinary incontinence (SUI) in women has seen evolving treatments, with urethral support becoming key. Modern synthetic sling procedures, including retropubic, obturator, and single-incision types, represent significant advancements.

Area of Science:

  • Urology
  • Gynecology
  • Medical Engineering

Background:

  • Stress urinary incontinence (SUI) affects many women, with historical treatments focusing on urethral support.
  • Early surgical innovations in the 1970s and 1980s faced challenges with reproducibility and universal acceptance.
  • The development of tension-free synthetic midurethral slings revolutionized SUI treatment in the 1990s.

Purpose of the Study:

  • To review the historical evolution of stress urinary incontinence treatments.
  • To highlight the pivotal role of synthetic sling procedures in modern urogynecology.
  • To categorize current synthetic sling techniques for SUI.

Main Methods:

  • Historical review of surgical techniques for stress urinary incontinence.
  • Analysis of innovations in urethral support procedures.

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  • Classification of contemporary synthetic sling methodologies.
  • Main Results:

    • Urethral support is the cornerstone of effective stress urinary incontinence correction.
    • Tension-free synthetic midurethral slings marked a paradigm shift in SUI management.
    • Current synthetic sling procedures include retropubic, obturator, and single-incision approaches.

    Conclusions:

    • Synthetic sling procedures have become a mainstay in treating female stress urinary incontinence.
    • The evolution of slings demonstrates continuous innovation in minimally invasive urogynecologic surgery.
    • Understanding different sling types is crucial for optimizing patient outcomes in SUI management.