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Updated: Jul 11, 2026

An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis
Published on: October 4, 2018
Experimental infectious bursal disease in the ostrich (Struthio camelus)
A R Mendes1, M C R Luvizotto2, H F Ferrari2
1UNESP Laboratório de Virologia, Departamento de Apoio, Produção e Saúde Animal.
Abstract:
Clinically severe disease was produced in ostriches aged 4 weeks by oral infection with a virulent strain of infectious bursal disease virus (vIBDV), namely strain Faragher 52/70. Four days after infection the birds were humanely killed and tissue samples, including thymus, bursa of Fabricius (BF), brain and kidney were collected for examination. Histopathologically, the thymus and BF showed severe lymphoid depletion and necrosis, while immunolabelling with a polyclonal antibody demonstrated abundant viral antigen.
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