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Implementing rotavirus vaccination in Asia

Mathuram Santosham1, E Anthony S Nelson, Joseph S Bresee

  • 1Department of International Health, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, E8132, 621 N. Washington Street, Baltimore, MD 21205, USA. msantosh@jhsph.edu

Vaccine
|September 21, 2007
PubMed

Insights

Rotavirus vaccines are recommended for national immunization programs in Asia. Further data on disease burden and economic impact are needed for widespread implementation to reduce childhood illness.

Area of Science:

  • Pediatrics
  • Vaccinology
  • Public Health

Background:

  • Rotavirus is a significant cause of childhood morbidity and mortality in Asia.
  • The Asian Pacific Pediatric Association (APPA) and international experts convened to discuss rotavirus vaccine implementation.
  • Existing rotavirus vaccines are safe, well-tolerated, and efficacious, with more candidates in development.

Purpose of the Study:

  • To summarize recommendations for rotavirus vaccine integration into National Immunization Programmes (NIP) in Asian countries.
  • To highlight the need for additional disease burden and economic evaluation data for policy decisions.
  • To address implementation considerations, including co-administration with other vaccines.

Main Methods:

  • Expert consensus and discussion during the 2006 APPA meeting.
  • Review of existing rotavirus vaccine data (safety, efficacy).
  • Consideration of disease burden and economic evaluation requirements.

Main Results:

  • Strong recommendation for rotavirus vaccine use in Asian NIPs.
  • Agreement on the necessity of further disease burden data and economic evaluations for nationwide implementation.
  • Discussion of practical aspects like concomitant vaccine use.

Conclusions:

  • Rotavirus vaccines offer substantial potential to decrease rotavirus disease burden in Asian children.
  • Policy decisions on vaccine introduction require robust data and economic assessments.
  • Strategic implementation planning is crucial for maximizing vaccine impact on child health in Asia.

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