Preventing postnatal growth failure--the significance of feeding when the preterm infant is clinically stable

Nutrition guidelines and growth targets for preterm infants are currently based upon the reference standard of intrauterine growth and fetal nutrient accretion rates. This may not be an entirely appropriate standard--it is rarely achieved in clinical practice. Postnatal growth failure of very preterm infants is a universal problem with potentially significant, adverse neurological and health outcomes. The nutrient deficit that accumulates in the early weeks postdelivery when the preterm infant is clinically unstable is difficult to recover. Weight, length and head circumference measurements remain important clinical indicators of growth but composition of weight gain is emerging as a necessary measure in determining the adequacy of nutrition intake and growth. Recommended protein and energy intakes for very preterm infants are difficult to achieve with commercial human milk fortifiers and during hospitalisation, targeting the fortification of human milk to optimise the protein to energy ratio of milk feeds is necessary to ensure appropriate composition of weight gain. Postdischarge, continued fortification of human milk feeds may be required for a limited period of time for preterm infants with suboptimal weight for corrected age.

The following systematic review is aimed to derive evidence-based best practice guidelines for prevention of postnatal growth failure of very preterm infants who are clinically stable and growing. The focus is on reviewing the standard upon which ideal growth and nutrition guidelines are based and targeting fortification to maximise the protein to energy ratio in human milk feeds to ensure appropriate composition of weight gain. Directions for future research are provided. For the literature review the data bases Medline, EMBASE, CINAHL, the Cochrane Library and reference lists of review articles were reviewed to December 2006. A hand search of paediatric and perinatal journals was also conducted.