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Updated: Jul 11, 2026
10:02
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
Published on: November 3, 2016
Cerebral palsy and congenital malformations
Ester Garne1, Helen Dolk, Inge Krägeloh-Mann
1Paediatric Department, Kolding Hospital, DK-6000 Kolding, Denmark. Egarne@health.sdu.dk
Summary
Congenital malformations, particularly cerebral ones, are common in children with cerebral palsy (CP). These malformations are more frequent in the CP population than in livebirths, with specific patterns observed.
Area of Science:
- Pediatric Neurology
- Developmental Pediatrics
- Clinical Genetics
Background:
- Cerebral palsy (CP) is a complex neurological disorder affecting movement and posture.
- Congenital malformations are known to be associated with CP, but their prevalence and specific types require detailed investigation.
Purpose of the Study:
- To determine the proportion of children diagnosed with cerebral palsy (CP) who also present with congenital malformations.
- To differentiate between cerebral and non-cerebral congenital malformations in children with CP.
Main Methods:
- Utilized data from 11 European Cerebral Palsy registries (SCPE) for children born between 1976 and 1996.
- Classified malformations into recognized syndromes, chromosomal anomalies, cerebral, and non-cerebral types.
- Compared prevalence rates with a European database of congenital malformations (EUROCAT).
Main Results:
- 11.9% of children with CP (547/4584) had congenital malformations.
- Cerebral malformations, including microcephaly and hydrocephaly, were most common (8.6% of all CP children).
- Children born at term showed a significantly higher prevalence of cerebral malformations compared to preterm infants (12.1% vs. 2.1%).
Conclusions:
- Cerebral malformations are significantly more prevalent in children with CP than in the general livebirth population.
- Malformations near the brain (e.g., facial clefts) were more common in CP, while those further away (e.g., renal) were more common in the general population.
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