Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Self-assembled elastin-like polypeptide particles.

Jill L Osborne1, Robin Farmer, Kimberly A Woodhouse

  • 1Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Canada M5S 3E5.

Acta Biomaterialia
|September 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic Insulin Analogue Concentrations at Infusion Sites Enhanced the Pro-Inflammatory Response and Apoptosis in an In Vitro Macrophage-Material Interaction Model.

ACS pharmacology & translational science·2024
Same author

MyD88-dependent Toll-like receptor 2 signaling modulates macrophage activation on lysate-adsorbed Teflon™ AF surfaces in an <i>in vitro</i> biomaterial host response model.

Frontiers in immunology·2023
Same author

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces.

Journal of visualized experiments : JoVE·2020
Same author

Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.

Genome biology·2017
Same author

Electrospun fiber constructs for vocal fold tissue engineering: effects of alignment and elastomeric polypeptide coating.

Acta biomaterialia·2014
Same author

Gene expression signatures of coronary heart disease.

Arteriosclerosis, thrombosis, and vascular biology·2013
Same journal

Corrigendum to "Senescent endothelial cells' response to the degradation of bioresorbable scaffold induces intimal dysfunction accelerating in-stent restenosis" [Acta Biomaterialia 166 (2023) 266-277].

Acta biomaterialia·2026
Same journal

Colorectum and embedded networks of nerve fibers present auxetic responses during uniaxial circumferential extension.

Acta biomaterialia·2026
Same journal

Music-Inspired Acoustic-Piezoelectric Stimulation Accelerates Extracellular Vesicle Production and Programs Therapeutic Function.

Acta biomaterialia·2026
Same journal

Mutant superoxide dismutase 1-catalyzed hydrogen therapy for amyotrophic lateral sclerosis achieved by intercepting oxidative stress-neuroinflammation crosstalk.

Acta biomaterialia·2026
Same journal

Injectable pH-responsive gelatin methacryloyl hydrogel for cuproptosis-synergized sunitinib therapy and immune reprogramming in clear cell renal cell carcinoma.

Acta biomaterialia·2026
Same journal

Corrigendum to "Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy" [Acta Biomaterialia 2025, 194, 153-168].

Acta biomaterialia·2026
See all related articles

Researchers explored self-assembling elastin-based copolymers for drug delivery. They found that modifying solvent systems and using cross-linking can optimize particle size and stability for potential applications.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Elastin-based block copolymers offer unique properties for biomaterial applications.
  • Understanding self-assembly is crucial for controlling particle characteristics.

Purpose of the Study:

  • Investigate the self-assembly of recombinant elastin-based block copolymers.
  • Characterize particle formation, dynamics, morphology, and stability.
  • Explore methods for optimizing particle properties for drug delivery.

Main Methods:

  • Inverted microscopy and dynamic light scattering for particle characterization.
  • Scanning and transmission electron microscopy for morphology and stability assessment.
  • Evaluation of polyethylene glycol (PEG) concentration and glutaraldehyde cross-linking effects.

Related Experiment Videos

Main Results:

  • Self-assembly above a critical temperature yielded nano- and micron-sized particles.
  • Larger particles grew via coalescence, with some reversibility and hysteresis.
  • High PEG concentrations reduced coalescence and settling, enhancing stability.
  • Glutaraldehyde cross-linking further stabilized the particles.

Conclusions:

  • Particle size and stability can be optimized by adjusting solvent systems.
  • Elastin-based polypeptides show promise as particulate drug carriers.
  • This research provides a foundation for developing advanced drug delivery systems.