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Solid-state properties of tobramycin.

A K Dash1, R Suryanayanan

  • 1Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis 55455.

Pharmaceutical Research
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

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This study characterizes tobramycin monohydrate, revealing its dehydration to metastable anhydrous tobramycin and subsequent transition to a stable form. These findings are crucial for understanding tobramycin

Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry

Background:

  • Tobramycin is an aminoglycoside antibiotic with critical clinical applications.
  • Understanding its solid-state properties is essential for formulation and stability.

Purpose of the Study:

  • To characterize tobramycin from different sources.
  • To investigate its hydration state and polymorphic behavior.
  • To determine the thermodynamic relationship between anhydrous forms.

Main Methods:

  • Powder X-ray diffractometry
  • Differential Scanning Calorimetry (DSC)
  • Karl Fischer Titrimetry

Main Results:

  • Tobramycin was identified as tobramycin monohydrate.

Related Experiment Videos

  • Heating induced dehydration to metastable anhydrous tobramycin (m.p. 164°C).
  • Metastable form transformed into stable anhydrous tobramycin (m.p. 217°C) in a monotropic transition.
  • Free energy difference between forms calculated as 348 cal·mol⁻¹ at 25°C.
  • DSC heating rate and sample size influenced thermal event enthalpy values, attributed to trace moisture.

    • Conclusions:

    • Tobramycin monohydrate undergoes a monotropic polymorphic transition to a stable anhydrous form.
    • Trace moisture significantly impacts thermal analysis results.
    • The characterized solid-state properties are vital for tobramycin drug development.