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Related Experiment Video

Updated: Jul 11, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Androgen receptor modulation: lessons learned from beyond the prostate.

Nima Sharifi¹, William D Figg

¹Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. nima.sharifi@nih.gov

Cancer Biology & Therapy

|September 21, 2007

Summary

This summary is machine-generated.

A new compound degrades the androgen receptor (AR), offering a novel approach to treating prostate diseases like prostate cancer and benign prostatic hyperplasia (BPH) by targeting AR function.

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Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

Published on: October 24, 2019

Area of Science:

Oncology
Endocrinology
Molecular Biology

Background:

The androgen receptor (AR) is a key transcription factor in prostate cancer and benign prostatic hyperplasia (BPH).
Current treatments for prostate diseases, including medical castration and AR antagonists, face limitations like AR reactivation, leading to castrate-resistant prostate cancer.
AR modulation is crucial for managing these conditions, necessitating novel therapeutic strategies.

Purpose of the Study:

To explore a novel compound that degrades the androgen receptor (AR).
To investigate the potential of this AR-degrading compound for treating prostate diseases, including prostate cancer.

Main Methods:

Review of recent findings on a compound that degrades AR.
Examination of the compound's mechanism, including induction of AR dissociation from coactivators.
Biochemical analysis of the compound's action.

Main Results:

Identification of a compound capable of degrading the androgen receptor (AR).
Demonstration that the compound induces dissociation of AR from its coactivator.
Exploration of the compound's biochemical properties and potential therapeutic applications.

Conclusions:

A novel compound effectively degrades the androgen receptor (AR).
This AR-degrading compound and its mechanism may offer new therapeutic avenues for prostate cancer.
Further research into this compound's biochemistry could impact prostate disease treatment.