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Published on: June 16, 2020
Pulmonary and sinusal changes in 45 patients with primary immunodeficiencies: computed tomography evaluation
Maria Pia Bondioni1, Marzia Duse, Alessandro Plebani
1Department of Radiology, University of Brescia-Italy. bondioni.pia@tin.it
Journal of Computer Assisted Tomography
|September 21, 2007
Summary
Pulmonary changes and chronic sinusitis are common in agammaglobulinemia (AG) and common variable immunodeficiency (CVID). However, lung lesion severity does not correlate with immunodeficiency type or sinus issues.
Area of Science:
- Immunology
- Pulmonology
- Radiology
Background:
- Primary immunodeficiencies like agammaglobulinemia (AG) and common variable immunodeficiency (CVID) are associated with increased susceptibility to infections.
- Pulmonary complications and chronic sinusitis are frequently observed in patients with these conditions.
Purpose of the Study:
- To identify and quantify pulmonary changes in patients with AG and CVID.
- To assess the incidence, type, and severity of chronic sinusitis and its relationship to pulmonary changes in these patients.
Main Methods:
- Computed tomography (CT) of the lungs and paranasal sinuses was performed on 45 patients (18 with AG, 27 with CVID).
- Analysis focused on identifying and quantifying pulmonary abnormalities and chronic sinusitis findings.
Main Results:
- Pulmonary changes were present in 57.7% of patients, with a trend towards higher frequency in CVID.
- Bronchiectasis was observed in both groups, but without statistical significance.
- Chronic sinusitis was detected in 41 of 45 patients, with no significant difference between AG and CVID groups.
- Longitudinal follow-up showed no correlation between bronchial and sinusal abnormalities.
Conclusions:
- CT imaging reveals that the type and severity of lung lesions in AG and CVID patients do not correlate with the specific immunodeficiency type.
- Sinus involvement severity also does not correlate with the extent or type of pulmonary lesions.
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