Related Experiment Video
Updated: Jul 11, 2026
07:07
A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Online clearance measurement in high-efficiency hemodiafiltration
M Gross1, A Maierhofer, C Tetta
1Fresenius Medical Care Deutschland GmbH, R&D International, Bad Homburg, Germany. Malte.gross@fmc-ag.com
Kidney International
|September 21, 2007
Summary
Ionic dialysance measurement using conductivity variation is now valid for online hemodiafiltration. This method accurately reflects urea clearance in convective therapies, offering a precise alternative for monitoring treatment effectiveness.
Area of Science:
- Nephrology
- Biomedical Engineering
- Clinical Chemistry
Background:
- Ionic dialysance measurement via conductivity variation is standard in hemodialysis.
- Its applicability in highly convective therapies like online hemodiafiltration requires validation.
Purpose of the Study:
- To derive and validate a new model for measuring ionic dialysance using conductivity variation in online hemodiafiltration.
- To assess the reliability of this method as a surrogate for urea clearance.
Main Methods:
- A novel model for ionic dialysance measurement was developed.
- The method was validated in 12 patients undergoing pre- and postdilution online hemodiafiltration.
- Agreement with blood-side urea clearance was assessed under varying conditions.
Main Results:
- A very good clinical agreement was observed between ionic dialysance (conductivity variation) and blood-side urea clearance.
- Neither pre- vs. postdilution nor substitution fluid flow rate significantly impacted this agreement.
- Ionic dialysance measurement by conductivity variation proved precise and easy to perform.
Conclusions:
- Conductivity variation is a reliable method for measuring ionic dialysance in online hemodiafiltration.
- This method serves as an excellent surrogate for urea clearance in highly convective therapies.
- The findings support the use of conductivity variation for enhanced monitoring of hemodiafiltration treatments.
Related Concept Videos
01:25Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
01:25Hemodialysis I: Introduction
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
01:24Hemodialysis II: Procedure and Complications
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
01:23Renal Clearance
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
01:15Dialysis
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...