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Published on: November 10, 2021
Fetuin-A is not associated with mortality in chronic kidney disease
J H Ix1, M G Shlipak, M J Sarnak
1Division of Nephrology and Hypertension, University of California San Diego, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA. joeix@ucsd.edu
Kidney International
|September 21, 2007
Summary
Serum fetuin-A does not predict mortality in chronic kidney disease. This study found no link between fetuin-A levels and death from any cause or cardiovascular disease in patients with stage 3-4 CKD.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biochemistry
Background:
- Fetuin-A, a serum protein, inhibits vascular calcification.
- Lower fetuin-A levels are linked to increased vascular calcification and mortality in end-stage renal disease.
- The role of fetuin-A in mortality risk for earlier stages of chronic kidney disease (CKD) is less understood.
Purpose of the Study:
- To investigate the association between serum fetuin-A levels and all-cause and cardiovascular mortality.
- To analyze fetuin-A's predictive value in non-diabetic patients with stage 3-4 CKD.
Main Methods:
- Analysis of data from 822 participants in the Modification of Diet in Renal Disease study (stages 3-4 CKD).
- Baseline serum fetuin-A levels were measured.
- Cox proportional hazard models were used to assess mortality risk over a median follow-up of 9.5 years.
Main Results:
- No significant association was found between the highest or lowest tertiles of serum fetuin-A and all-cause mortality.
- Similarly, no association was observed between fetuin-A levels (tertiles or continuous) and cardiovascular mortality.
- The study included individuals with glomerular filtration rates between 13-55 ml/min/1.73 m(2).
Conclusions:
- Serum fetuin-A levels are not associated with all-cause or cardiovascular mortality in individuals with predominantly non-diabetic stage 3 or 4 CKD.
- These findings suggest fetuin-A may not be a useful prognostic biomarker for mortality in this CKD population.
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