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Osteoporosis: non-hormonal treatment
1Division of Bone Diseases (World Health Organization Collaborating Center for Osteoporosis Prevention), Department of Rehabilitation and Geriatrics, University Hospitals, Geneva, Switzerland.
Climacteric : the Journal of the International Menopause Society
|October 27, 2007
Summary
Osteoporosis treatments like bisphosphonates, hormone therapy, and denosumab effectively reduce fracture risks. Calcium and vitamin D also help prevent falls and hip fractures, especially in older adults.
Area of Science:
- Bone biology and pharmacology
- Geriatric medicine
- Endocrinology
Background:
- Osteoporosis treatment has advanced with new drugs and administration schedules.
- Long-term safety data for osteoporosis therapies are increasingly available.
Purpose of the Study:
- To review current osteoporosis treatments and their efficacy in reducing fracture risk.
- To highlight novel agents and their impact on bone mineral density.
Main Methods:
- Review of clinical trials and meta-analyses on osteoporosis medications.
- Analysis of fracture risk reduction data for various agents.
- Comparison of bone mineral density changes with different treatments.
Main Results:
- Alendronate, risedronate, strontium ranelate, and zoledronate reduce vertebral and hip fracture risks.
- Calcium and vitamin D supplementation decreases fall and hip fracture risk in institutionalized patients.
- Denosumab demonstrates potent bone resorption inhibition and increases bone mineral density.
Conclusions:
- Multiple pharmacologic agents effectively reduce fracture risk in osteoporosis.
- Newer agents like denosumab show promising results in improving bone density.
- Combination therapy with parathyroid hormone and bone resorption inhibitors does not appear to offer additional benefits.
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