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A novel formulation for mebeverine hydrochloride
Sameh M Abdel-Hamid1, Seham E Abdel-Hady, Abdel-Hamid A El-Shamy
1Department of Drug Technology, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, Egypt. samoh78@hotmail.com
Abstract:
The antispasmodic drug mebeverine hydrochloride was formulated into a film-forming gel to be used as a topical local anesthetic. A mixture of cellulose derivatives was used as a base. Additives were used to enhance the release as well as the residence time. Formulations were characterized in terms of drug release, mucoadhesion and rheology. Clinically, the selected formula has shown faster onset (p = 0.0156), longer duration (p = 0.0313), better film residence (p = 0.0313), and no foreign body sensation (p = 0.0313) in comparison to Solcoseryl dental paste. Histopathological examination showed no change in inflammatory cells count, concluding that this topical anesthetic is efficacious and safe orally.
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