Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Reply.

Archives of pathology & laboratory medicine·2026
Same author

Rebuttal to "Bronchiolocentric interstitial pneumonia is a more accurate interstitial lung disease classification than hypersensitivity pneumonitis: pro".

American journal of respiratory and critical care medicine·2026
Same author

Bronchiolocentric interstitial pneumonia is a more accurate interstitial lung disease classification than hypersensitivity pneumonitis: con.

American journal of respiratory and critical care medicine·2026
Same author

Immunohistochemical characterization of peritoneal inclusion cysts with squamous metaplasia.

Histopathology·2025
Same author

Clinical ERG break-apart fluorescence in situ hybridization assay: practical utility and lessons from an 8-year tertiary institution experience.

American journal of clinical pathology·2025
Same author

Substituting bronchiolocentric interstitial pneumonia for hypersensitivity pneumonitis: a word of caution.

The European respiratory journal·2025

Related Experiment Video

Updated: Jul 11, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Nonspecific interstitial pneumonia: pathologic features and clinical implications.

Jeffrey L Myers1

  • 1Division of Anatomic Pathology, The University of Michigan, Ann Arbor, Michigan, USA. myerjeff@med.umich.edu

Seminars in Diagnostic Pathology
|September 22, 2007
PubMed
Summary
This summary is machine-generated.

Nonspecific interstitial pneumonia (NSIP) is a distinct chronic lung disease that requires differentiation from usual interstitial pneumonia (UIP). Key diagnostic features in lung biopsies help distinguish NSIP, which has a better prognosis.

More Related Videos

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Jul 11, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Area of Science:

  • Pulmonology
  • Pathology
  • Radiology

Background:

  • Nonspecific interstitial pneumonia (NSIP) is a chronic interstitial lung disease.
  • Accurate diagnosis is crucial as NSIP has a more favorable prognosis than idiopathic pulmonary fibrosis (IPF).
  • Distinguishing NSIP from other idiopathic interstitial pneumonias, particularly usual interstitial pneumonia (UIP), is essential.

Purpose of the Study:

  • To highlight the key diagnostic criteria for differentiating NSIP from UIP.
  • To emphasize the importance of integrating clinical, radiological, and pathological findings for NSIP diagnosis.

Main Methods:

  • Diagnosis relies on characteristic findings from surgical lung biopsies.
  • Integration of clinical presentation and radiological imaging is necessary.
  • Histopathological examination focuses on specific features to differentiate NSIP from UIP.

Main Results:

  • NSIP is characterized by the absence of heterogeneous lung involvement, architectural distortion (fibrotic scarring, honeycomb change), and fibroblast foci, which are typical of UIP.
  • Surgical lung biopsy provides critical histopathological evidence for NSIP diagnosis.
  • NSIP patients may have associated conditions but generally exhibit a better prognosis compared to UIP/IPF.

Conclusions:

  • NSIP is a distinct clinicopathological entity within interstitial lung diseases.
  • Histopathological features, particularly the absence of UIP hallmarks, are key to diagnosing NSIP.
  • Accurate differentiation of NSIP from UIP is vital for appropriate patient management and prognosis.