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Infantile hemangioendothelioma of liver: report of two cases
Nirmal Kumar Bhattacharyya1, Uttara Chatterjee, Sharmila Sen
1Department of Pathology, IPGME&R and SSKM Hospital, Kolkata, West Bengal.
Insights
Infantile hemangioendothelioma, a common liver tumor in infants, can aggressively impact health. This report details two infant cases presenting with hepatic masses and heart failure symptoms.
Area of Science:
- Pediatric Oncology
- Hepatology
- Vascular Tumors
Background:
- Infantile hemangioendothelioma is the most frequent mesenchymal tumor of the liver in infants.
- While typically benign, it can exhibit aggressive behavior and significant morbidity.
Observation:
- Two infant female cases presented with nodular hepatic masses.
- Clinical presentation included signs of heart failure.
Findings:
- Histopathology revealed intercommunicating blood vessels lined by plump endothelial cells.
- Immunohistochemistry confirmed CD-34 positivity in endothelial cells and cytokeratin positivity in entrapped biliary channels.
Implications:
- Early recognition and diagnosis of infantile hemangioendothelioma are crucial.
- Understanding the aggressive potential informs management strategies for affected infants.
Abstract:
Infantile hemangioendothelioma, the commonest mesenchymal tumour of liver in infancy, though benign in nature, may behave aggressively. Here reports of two such cases are presented. Both were girls and less than 1-year old. Grossly, they presented with nodular hepatic masses with features of heart failure. Histopathology of both liver masses showed intercommunicating bloodvessels, lined by single layer of plump endothelial cells showing CD-34 positivity by immunohistochemistry. Entrapped biliary channels within tumour mass showed cytokeratin positivity.
