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"Paramyxovirus-like" intranuclear inclusions occurring in the nervous system in diverse unrelated conditions

M Hayano, J H Sung, A R Mastri

    Journal of Neuropathology and Experimental Neurology
    |May 1, 1976
    PubMed

    Insights

    Intranuclear inclusions previously linked to multiple sclerosis (MS) were found in patients with various neurological conditions. These findings suggest these inclusions are not specific to MS and may indicate cellular degeneration.

    Area of Science:

    • Neuropathology
    • Cellular Biology
    • Infectious Diseases

    Background:

    • Filamentous intranuclear inclusions, termed "paramyxovirus-like" inclusions, have been described in active multiple sclerosis (MS).
    • The specific etiology and significance of these inclusions remain debated, with a viral origin frequently hypothesized.

    Purpose of the Study:

    • To investigate the specificity of "paramyxovirus-like" intranuclear inclusions.
    • To explore alternative explanations for the presence of these inclusions beyond a viral association.

    Main Methods:

    • Incidental observation of filamentous intranuclear inclusions in four patients with diverse neurological disorders.
    • Review of existing virological and immunological data regarding these inclusions.
    • Analysis of cellular context (degenerating/autolyzed cells) in biopsied/autopsied tissues.

    Main Results:

    • Intranuclear inclusions morphologically similar to those in MS were observed in patients with rabies, mannosidosis, metachromatic leukodystrophy, cerebral aneurysm, and ischemic infarcts.
    • No definitive virological or immunological evidence supports a viral nature for these inclusions.
    • Inclusions were predominantly found in degenerating or autolyzed cells.

    Conclusions:

    • The observed intranuclear inclusions are not specific to multiple sclerosis and can be found in various conditions.
    • The findings support the hypothesis that these inclusions may represent nuclear chromatin alterations associated with cellular degeneration and autolysis.
    • Further research is needed to elucidate the precise nature of these inclusions.

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