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Updated: Jul 11, 2026
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Early prediction of outcome in very severe closed head injury
Sandeep Jain1, Satish B Dharap, Madhuri A Gore
1L.T.M. Medical College, Sion, Mumbai, India. sjain7172@yahoo.com
Background:
People with severe head injury and admission Glasgow Coma Scale (GCS) score < or =5 have a poor outcome and greatly strain limited resources.
Aim:
To identify patients with the best chances of survival, using routine clinical measures.
Methods:
People attending the trauma intensive care unit, who had isolated blunt head injury and GCS< or =5 and who had survived > or =4h, were included in the study, resuscitated and clinically assessed. The GCS score was followed serially after admission. Bivariate analysis of various parameters with outcome was performed using the chi-square test. Serial GCS scores were compared with admission GCS by paired t-testing.
Results:
Of the 102 patients who were studied prospectively, 78 (76.5%) died and 24 (23.5%) survived. Age, gender, pre-hospital delay and admission GCS scores were comparable between the two groups. Adequate spontaneous respiration, brisk pupillary light reactivity on admission and increase in GCS by at least 2 at 24h after admission significantly affected the outcome (p<0.05). In the presence of all these factors, the survival rate increased from 6.1% to 57.1% (p<0.001).
Conclusions:
People with GCS score < or =5 still have a reasonable chance of survival, so all patients should be aggressively managed initially. Better survival was observed among those with adequate spontaneous respiration, good pupillary reaction and improvement in GCS of at least 2 at 24h. These clinical parameters can help to predict survival and thus make best use of limited resources.
