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Reduction of DNA damage in older healthy adults by Tri E Tocotrienol supplementation

Siok-Fong Chin1, Noor Aini Abdul Hamid, Azian Abdul Latiff

  • 1Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Nutrition (Burbank, Los Angeles County, Calif.)
|September 22, 2007
PubMed
Abstract

Insights

Tri E Tocotrienol supplementation significantly reduced DNA damage and markers of aging, including sister chromatid exchange (SCE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG). This suggests a potential benefit in mitigating age-related cellular damage.

Area of Science:

  • Gerontology and Molecular Biology
  • Biochemistry and Oxidative Stress

Background:

  • The free radical theory of aging (FRTA) posits that accumulated cellular damage from free radicals contributes to age-related decline.
  • DNA damage is a key factor in aging, leading to various age-associated disorders.

Purpose of the Study:

  • To investigate the efficacy of Tri E Tocotrienol in mitigating DNA damage in humans.
  • To evaluate the impact of Tri E Tocotrienol on biomarkers of oxidative stress and DNA integrity.

Main Methods:

  • A 6-month randomized, double-blinded, placebo-controlled study involving 64 participants aged 37-78.
  • Daily administration of 160 mg of Tri E Tocotrienol.
  • Analysis of DNA damage using comet assay, sister chromatid exchange (SCE) frequency, and chromosome 4 aberrations in blood samples.

Main Results:

  • Significant reduction in DNA damage (comet assay) observed at 3 and 6 months (P < 0.01).
  • Reduced SCE frequency after 6 months (P < 0.05), with a more pronounced effect in individuals over 50 (P < 0.01).
  • Significant decrease in urinary 8-hydroxy-2 -deoxyguanosine (8-OHdG) levels (P < 0.05), a marker of oxidative DNA damage.

Conclusions:

  • Tri E Tocotrienol supplementation demonstrates a beneficial effect in reducing DNA damage.
  • The observed reductions in DNA damage, SCE, and 8-OHdG suggest potential anti-aging properties.
  • Further research may explore Tri E Tocotrienol's role in managing age-related conditions.

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