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Controlling protein release from scaffolds using polymer blends and composites.

Patrick J Ginty1, John J A Barry, Lisa J White

  • 1School of Pharmacy, University of Nottingham, Nottingham, UK.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|September 22, 2007
PubMed
Summary

Researchers developed novel polymer materials to control protein release from poly(dl-lactic acid) scaffolds. Blending with polyethylene glycol or incorporating alginate fibers modified release kinetics for enhanced therapeutic delivery.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Poly(dl-lactic acid) (P(dl)LA) is a common biodegradable polymer used in tissue engineering and drug delivery.
  • Controlling the release rate of encapsulated proteins from P(dl)LA scaffolds is crucial for therapeutic efficacy.
  • Existing P(dl)LA scaffolds may have limitations in achieving desired protein release profiles.

Purpose of the Study:

  • To develop and characterize novel polymer blend and composite materials based on P(dl)LA.
  • To investigate the effect of incorporating polyethylene glycol (PEG), poly(caprolactone) (PCL) microparticles, or calcium alginate fibers on protein release kinetics.
  • To create scaffolds with tunable single and dual protein release profiles.

Main Methods:

  • Utilized supercritical carbon dioxide (scCO(2)) processing to create P(dl)LA blends and composites.
  • Incorporated PEG, PCL microparticles, and calcium alginate fibers into P(dl)LA scaffolds.
  • Analyzed protein release kinetics from the developed scaffold materials.

Main Results:

  • Blending P(dl)LA with hydrophilic PEG increased water uptake and accelerated protein release compared to P(dl)LA alone.
  • P(dl)LA/alginate composite scaffolds exhibited dual release kinetics, with faster initial release from alginate and slower release from P(dl)LA.
  • Incorporating PCL microparticles into P(dl)LA scaffolds retarded protein release due to the slow degradation of PCL.

Conclusions:

  • Polymer blending and composite formation using scCO(2) processing offer effective strategies to modulate protein release from P(dl)LA scaffolds.
  • The choice of incorporated material (PEG, alginate, PCL) allows for precise control over release kinetics, enabling tailored drug delivery systems.
  • These novel materials hold promise for advanced applications in regenerative medicine and controlled therapeutic protein delivery.