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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...

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Related Experiment Video

Updated: Jul 11, 2026

Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
07:49

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Oxidative stress in acute ischemic stroke.

Ayca Ozkul1, Ali Akyol, Cigdem Yenisey

  • 1Neurology Department, Medical Faculty, Adnan Menderes University, 09100, Aydin, Turkey. ozkulayca@hotmail.com

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|September 22, 2007
PubMed
Summary

Oxidative stress significantly impacts acute ischemic stroke severity. Elevated nitric oxide (NO) and malondialdehyde (MDA) levels correlate with poorer outcomes, suggesting a role in stroke pathogenesis.

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Area of Science:

  • Biochemistry
  • Neurology
  • Pathophysiology

Background:

  • Oxidative stress is implicated in the pathogenesis of acute ischemic stroke.
  • Free radical formation and oxidative damage may contribute to stroke severity.

Purpose of the Study:

  • To investigate the role of oxidative stress markers in acute ischemic stroke.
  • To correlate serum levels of nitric oxide (NO), malondialdehyde (MDA), and glutathione (GSH) with clinical outcomes in stroke patients.

Main Methods:

  • Serum levels of NO, MDA, and GSH were measured in 70 acute ischemic stroke patients within 48 hours of stroke onset.
  • Clinical outcomes were assessed using Canadian Neurological Scale (CNS) scores.
  • Results were compared to a control group of 70 healthy volunteers.

Main Results:

  • Serum NO, MDA, and GSH levels were significantly elevated in acute stroke patients compared to controls.
  • CNS scores showed a negative correlation with MDA and NO levels.
  • No significant correlation was found between GSH levels and CNS scores.

Conclusions:

  • Elevated oxidative stress markers (MDA, NO) are associated with poorer clinical outcomes in acute ischemic stroke.
  • Increased GSH levels might represent an adaptive response during the acute phase of ischemic stroke.