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Published on: August 25, 2023
The standard gamble showed better construct validity than the time trade-off.
Milo A Puhan1, Holger J Schünemann, Eric Wong
1Horten Centre, University of Zurich, Switzerland.
Journal of Clinical Epidemiology
|September 22, 2007
Summary
The standard gamble (SG) better measures health-related quality of life in Irritable Bowel Syndrome (IBS) patients than the time trade-off (TTO). The SG showed higher correlations with various health measures.
Area of Science:
- Health Economics
- Patient-Reported Outcomes
- Quality of Life Measurement
Background:
- Limited evidence exists comparing the cross-sectional validity of standard gamble (SG) and time trade-off (TTO) preference-based instruments.
- Irritable Bowel Syndrome (IBS) presents a relevant condition for evaluating these health valuation tools.
Purpose of the Study:
- To compare the cross-sectional validity of the standard gamble (SG) and time trade-off (TTO) in patients with Irritable Bowel Syndrome (IBS).
- To determine which instrument better reflects health-related quality of life and patient preferences in this population.
Main Methods:
- 96 IBS patients completed health state valuations using both SG and TTO.
- Patients also completed disease-specific (IBS questionnaire, Brief Pain Inventory) and generic (SF-36, Sickness Impact Profile) health measures, plus a global disease severity rating.
Main Results:
- The SG yielded a mean score of 0.84 (SD 0.16), while the TTO yielded 0.76 (SD 0.22).
- The SG demonstrated stronger correlations with the IBS questionnaire (0.36-0.47 vs. 0.15-0.42 for TTO), generic questionnaires (0.18-0.34 vs. 0.13-0.26), Brief Pain Inventory (0.27 vs. 0.11), and global disease severity (0.22 vs. 0.10).
- Correlations with SF-36 derived preferences were also higher for SG (0.31-0.43 vs. 0.27-0.31 for TTO).
Conclusions:
- The standard gamble (SG) exhibits superior cross-sectional validity compared to the time trade-off (TTO) in IBS patients.
- The SG appears to be a more effective tool for assessing health-related quality of life and patient preferences in this clinical group.
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