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Updated: Jul 11, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Natural products as a screening resource.

Alan L Harvey¹

¹Strathclyde Institute for Drug Research, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK. a.l.harvey@strath.ac.uk

Current Opinion in Chemical Biology

|September 22, 2007

Summary

Natural products offer diverse and drug-like compounds for drug discovery. Advances in analytical techniques and sourcing methods are revitalizing their use in pharmaceutical research.

Area of Science:

Medicinal Chemistry
Drug Discovery
Natural Products Chemistry

Background:

Natural products have historically been a primary source for novel drug leads.
The pharmaceutical industry's interest in natural products has waned.
Challenges in sourcing and analyzing natural products have hindered their use.

Purpose of the Study:

To highlight the renewed potential of natural products in drug discovery.
To discuss advancements enabling the use of natural products in screening.
To predict a resurgence in natural product-inspired drug development.

Main Methods:

Utilizing novel biodiversity sources for compound isolation.
Employing advanced analytical techniques like microcoil NMR and LC-MS-NMR.

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Published on: July 26, 2024

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Last Updated: Jul 11, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

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Published on: March 31, 2021

Bioassay-Guided Identification of Natural Products for Biocontrol by Thin Layer Chromatography-Direct Bioautography

Bioassay-Guided Identification of Natural Products for Biocontrol by Thin Layer Chromatography-Direct Bioautography

Published on: July 26, 2024

Developing synthetic and biosynthetic methods for natural product-like libraries.

Main Results:

Technical advances have mitigated difficulties in natural product screening.
Natural products offer a more diverse and drug-like chemical space than combinatorial libraries.
New methods are being developed to create screening libraries based on natural products.

Conclusions:

A revival of natural product-inspired drug discovery is anticipated.
Modern techniques make natural products a viable and promising avenue for pharmaceutical research.
The unique chemical diversity of natural products remains invaluable for identifying new drug candidates.