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Insulin secretion and sensitivity after partial hepatectomy in the rat
Research in Experimental Medicine. Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
|January 1, 1991
Summary
Following partial hepatectomy, rats initially show hyperinsulinemia (excessive insulin) and normal insulin sensitivity. This insulin hypersecretion resolves by day 7, while insulin sensitivity remains unchanged.
Area of Science:
- Metabolic Surgery
- Endocrinology
- Hepatology
Background:
- Partial hepatectomy (PH) in rats is known to induce hyperinsulinemia and glucose intolerance.
- This metabolic state may result from peripheral insulin resistance coupled with compensatory insulin hypersecretion.
Purpose of the Study:
- To investigate in vivo insulin secretion and sensitivity in rats following partial hepatectomy.
- To determine the temporal dynamics of insulin response and sensitivity after liver resection.
Main Methods:
- Intravenous glucose tolerance tests were performed at 1, 3, 7, and 14 days post-PH.
- Insulin sensitivity was assessed using a hyperinsulinemic-euglycemic clamp model with simultaneous infusion of glucose, insulin, adrenaline, and propranolol at 3 days post-PH.
Main Results:
- Plasma insulin levels during glucose infusion were significantly elevated at 1 and 3 days after PH compared to controls.
- By 7 and 14 days post-PH, insulin secretion in response to glucose returned to control levels.
- Insulin sensitivity, assessed via the clamp model, was not significantly different between PH and sham-operated rats at 3 days post-PH.
Conclusions:
- Partial hepatectomy induces a transient phase of insulin hypersecretion, evident as early as day 1 and resolving by day 7.
- Peripheral insulin sensitivity remains unaltered following partial hepatectomy.
- The observed glucose intolerance post-PH is likely due to insulin hypersecretion rather than insulin resistance.