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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Diffusion tensor imaging and tractography of median nerve: normative diffusion values.

Neslihan Kabakci¹, Bengi Gürses, Zeynep Firat

¹Department of Radiology, Yeditepe University Hospital, Devlet Yolu Ankara Cad. 102-104, 34752 Kozyataği, Istanbul, Turkey. nkabakci@yeditepe.edu.tr

AJR. American Journal of Roentgenology

|September 22, 2007

Summary

This study visualizes the human median nerve using diffusion tensor imaging, establishing normal fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values. These normative diffusion values serve as a reference for median nerve conditions.

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Area of Science:

Neuroimaging
Musculoskeletal Radiology
Diffusion Tensor Imaging

Background:

Median nerve abnormalities can significantly impact patient quality of life.
Accurate diagnostic tools are crucial for evaluating median nerve pathologies.
Diffusion tensor imaging (DTI) offers a promising non-invasive method for nerve assessment.

Purpose of the Study:

To visualize the human median nerve using diffusion tensor imaging (DTI).
To determine the normal fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of the median nerve.
To establish normative DTI parameters for the median nerve.

Main Methods:

Utilized a 3-T MRI system with a standard eight-channel sensitivity-encoding head coil.
Performed diffusion tensor imaging with a spin-echo echo-planar sequence and T1-weighted sequence for anatomic reference.
Calculated FA and ADC values automatically after tractography, with manual focal measurements at specific wrist and forearm levels.

Main Results:

Successfully visualized the median nerve using MR diffusion tensor tractography over approximately 77.5 mm.
Established normative diffusion values for the median nerve: FA of 0.709 ± 0.046 (SD) and ADC of 1.016 ± 0.129 x 10⁻³ mm²/s.
Observed statistically significant differences in FA at the flexor retinaculum and a decrease in FA with advancing age, alongside an increase in ADC.

Conclusions:

The established normative diffusion values for the human median nerve provide a crucial reference.
These values aid in the evaluation, diagnosis, and follow-up of median nerve entrapment, trauma, and regeneration.
DTI parameters can enhance the diagnostic accuracy and management of median nerve disorders.