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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
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Related Experiment Video

Updated: Jun 29, 2026

In Vivo 4-Dimensional Tracking of Hematopoietic Stem and Progenitor Cells in Adult Mouse Calvarial Bone Marrow
12:54

In Vivo 4-Dimensional Tracking of Hematopoietic Stem and Progenitor Cells in Adult Mouse Calvarial Bone Marrow

Published on: September 4, 2014

Dynamic visualization of thrombopoiesis within bone marrow.

Tobias Junt1, Harald Schulze, Zhao Chen

  • 1Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|September 22, 2007
PubMed
Summary

Platelet generation from megakaryocytes (MKs) in bone marrow (BM) was visualized in mice. Blood flow shear stress appears to drive proplatelet formation and release, a key step in thrombopoiesis.

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Related Experiment Videos

Last Updated: Jun 29, 2026

In Vivo 4-Dimensional Tracking of Hematopoietic Stem and Progenitor Cells in Adult Mouse Calvarial Bone Marrow
12:54

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Published on: September 4, 2014

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In Vivo Two-photon Imaging of Megakaryocytes and Proplatelets in the Mouse Skull Bone Marrow
07:58

In Vivo Two-photon Imaging of Megakaryocytes and Proplatelets in the Mouse Skull Bone Marrow

Published on: July 28, 2021

Area of Science:

  • Hematology
  • Biophysics
  • Cell Biology

Background:

  • Platelet production (thrombopoiesis) from megakaryocytes (MKs) in mammalian bone marrow (BM) is not fully understood.
  • The precise mechanisms governing platelet release remain a critical area of investigation in hematology.

Purpose of the Study:

  • To visualize the in vivo process of platelet generation within the bone marrow.
  • To investigate the role of biophysical forces, specifically fluid shear stress, in thrombopoiesis.

Main Methods:

  • Utilized multiphoton intravital microscopy to observe MKs and platelet formation in intact mouse bone marrow.
  • Conducted in vitro experiments to assess the effect of fluid shear on proplatelet production from MKs.

Main Results:

  • Megakaryocytes (MKs) were observed extending proplatelet-like protrusions into microvessels within the bone marrow.
  • Blood flow appeared to shear these extensions, leading to proplatelet release into circulation.
  • In vitro studies showed enhanced proplatelet production under fluid shear conditions.

Conclusions:

  • The study provides in vivo evidence supporting proplatelet formation within the bone marrow microenvironment.
  • Results suggest that hydrodynamic shear stress from blood flow is a significant biophysical factor regulating thrombopoiesis.