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Ciguatera poisoning.

Kira C Achaibar1, Simon Moore, Peter G Bain

  • 1Department of Clinical Neurosciences, Imperial College London, UK.

Practical Neurology
|September 22, 2007
PubMed
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This summary is machine-generated.

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Ciguatera poisoning from tropical fish caused a man to develop gastrointestinal and neurological symptoms, including a small fibre neuropathy. His symptoms gradually improved over ten months.

Area of Science:

  • Toxicology
  • Neuroscience
  • Clinical Neurology

Background:

  • Ciguatera poisoning is caused by consuming tropical and subtropical fish contaminated with ciguatoxins.
  • Ciguatoxins are heat-stable, lipid-soluble cyclic polyether compounds.
  • These toxins affect voltage-sensitive sodium channels, leading to neural hyperexcitability.

Observation:

  • A 45-year-old man in Antigua experienced gastrointestinal symptoms after eating red snapper and grouper.
  • Neurological symptoms, including temperature reversal and pruritus, appeared 24-48 hours later.
  • A small fibre peripheral neuropathy was diagnosed.

Findings:

  • The patient exhibited paradoxical dysaesthesia (temperature reversal), intense pruritus, and increased nociception.
  • These neurological manifestations were attributed to ciguatoxin-induced small fibre neuropathy.

Related Experiment Videos

  • The patient's condition showed improvement over a 10-month period.

    • Implications:

    • This case highlights the diverse neurological manifestations of ciguatera poisoning.
    • Early recognition of ciguatera fish poisoning is crucial for appropriate patient management.
    • Understanding the pathophysiology of ciguatoxins aids in diagnosing and treating related neuropathies.