Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

Intestinal Obstruction II: Pathophysiology

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

Cellular Adaptation IV: Dysplasia and Metaplasia

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of Hepatocellular Carcinoma in Patients with Glycogen Storage Disease: a Single Center Retrospective Study.

Journal of Korean medical science·2020

Same author

Multiplex Ligation-dependent Probe Amplification Analysis Subsequent to Direct DNA Full Sequencing for Identifying <i>ATP7B</i> Mutations and Phenotype Correlations in Children with Wilson Disease.

Journal of Korean medical science·2018

Same author

Clinical and ABCB11 profiles in Korean infants with progressive familial intrahepatic cholestasis.

World journal of gastroenterology·2016

Same author

Abatacept alleviates severe autoimmune symptoms in a patient carrying a de novo variant in CTLA-4.

The Journal of allergy and clinical immunology·2015

Same author

Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease.

Journal of pediatric gastroenterology and nutrition·2015

Same author

Diencephalic syndrome: a frequently neglected cause of failure to thrive in infants.

Korean journal of pediatrics·2015

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Immunostaining to Visualize Murine Enteric Nervous System Development

Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

[Intestinal neuronal dysplasia].

Jeong Kee Seo¹

¹Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital, Seoul National University College of Medicine, Seoul, Korea. jkseo@snu.ac.kr

The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi

|September 22, 2007

Summary

Intestinal neuronal dysplasia (IND) type B, a submucosal plexus disease, causes chronic constipation. Recent data clarifies its causes and management, aiding diagnosis and treatment strategies for this gastrointestinal condition.

Area of Science:

Gastroenterology
Pediatric Surgery
Pathology

Background:

Intestinal neuronal dysplasia (IND) type B affects the submucosal plexus, leading to chronic intestinal obstruction and severe constipation.
IND is classified under intestinal dysganglionoses and shares clinical similarities with Hirschsprung's disease.
The etiology of IND, whether congenital or acquired, has been a subject of debate.

Purpose of the Study:

To review current knowledge on controversial aspects of Intestinal Neuronal Dysplasia type B.
To consolidate information on the etiology, classification, diagnostic criteria, and therapeutic interventions for IND.

Main Methods:

Literature review of recent data and consensus reports on IND.
Analysis of existing studies on the pathogenesis and management of IND.

More Related Videos

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Innervation of Human Intestinal Organoids

Innervation of Human Intestinal Organoids

Published on: January 17, 2025

Related Experiment Videos

Last Updated: Jul 11, 2026

Immunostaining to Visualize Murine Enteric Nervous System Development

Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Innervation of Human Intestinal Organoids

Innervation of Human Intestinal Organoids

Published on: January 17, 2025

Main Results:

Recent advancements have improved the understanding of IND's pathogenesis.
Consensus reports offer clearer diagnostic and management guidelines.

Conclusions:

Further research and standardized approaches are needed for effective IND management.
Enhanced understanding aids in differentiating IND from similar conditions and optimizing patient care.