Related Experiment Video
Updated: Jul 11, 2026
Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
Published on: January 17, 2025
Cognitive-behavioral therapy for adolescents with inflammatory bowel disease and subsyndromal depression
Eva Szigethy1, Elyse Kenney1, Johanna Carpenter1
1Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
Objective:
To examine the feasibility and efficacy of a manual-based cognitive-behavioral therapy (CBT) in reducing depressive symptomatology in adolescents with inflammatory bowel disease (IBD). Primary and Secondary Control Enhancement Therapy-Physical Illness (PASCET-PI) modified for youths with IBD was compared to treatment as usual (TAU), plus an information sheet about depression, without therapist contact using assessable patient analysis.
Method:
Following assessment, participants 11 to 17 years old with IBD and mild to moderate subsyndromal depression were randomly assigned to PASCET-PI (n = 22) or comparison treatment (n = 19). Primary outcome measures at baseline (T1) and 12 to 14 weeks posttreatment (T2) were Children's Depression Inventory (child/parent report), Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS), Children's Global Assessment Scale, and Perceived Control Scale for Children.
Results:
The PASCET-PI group showed significantly greater improvement in Children's Depression Inventory (child/parent report), Children's Global Assessment Scale, and Perceived Control Scale for Children posttreatment than the comparison group.
Conclusions:
Screening and treatment of depressive symptoms in pediatric settings is feasible. PASCET-PI may be an efficacious intervention for subsyndromal depression in adolescents with IBD, although comparison with a more active treatment is necessary to attribute the improvement to PASCET-PI.
Clinical Trial Registration Information:
URL: http://clinicaltrials.gov. Unique identifier: NCT00446238.
Related Concept Videos
01:25Cognitive Therapy
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
01:24Rational Emotive Behavior Therapy
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...