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Updated: Jul 11, 2026

Membrane Potential Dye Imaging of Ventromedial Hypothalamus Neurons From Adult Mice to Study Glucose Sensing
Published on: November 27, 2013
Glucose-monitoring neurons in the nucleus accumbens
Szilárd Papp1, Balázs Lukáts, Gábor Takács
1Pécs University, Medical School, Institute of Physiology of the Hungarian Academy of Sciences, Pécs, Hungary. szilard.papp@aok.pte.hu
Abstract:
The nucleus accumbens, a key structure of the limbic circuitry, is involved in the regulation of motivated behaviors. The accumbens performs its roles via interconnections with brain areas where glucose-monitoring neurons have been localized. To search for such integrative chemosensory cells here, extracellular single neuron activity was recorded in the nucleus accumbens of Wistar rats by means of multibarreled glass microelectrodes during microelectrophoretic administration of D-glucose and other chemicals. Every fourth neuron tested changed in activity in response to glucose. Accumbens cells also displayed distinct gamma-amino-n-butyric acid type sensitivity. It is suggested that differential distribution of the chemosensory units, demonstrated between subdivisions of the nucleus accumbens, has particular significance with respect to functional dichotomy of the shell and core subregions.
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