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Updated: Jul 11, 2026

The MultiBac Protein Complex Production Platform at the EMBL
Published on: July 11, 2013
Engineering eukaryotic protein factories
1School of Biological and Biomedical Sciences, Durham University, South Road, Durham DH1 3LE, UK. martin.schroeder@durham.ac.uk
Abstract:
The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression systems. However, the productivity per cell has remained unchanged for more than 10 years. The engineering of the ER-resident protein folding machinery is discussed together with an overview of signal transduction pathways activated by heterologous protein overexpression to increase cell specific productivities.
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