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Updated: Jul 11, 2026
A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
Published on: April 13, 2010
Plasma resistin levels in asthmatics as a marker of disease state
Jeffrey Larochelle1, John Freiler, John Dice
1The Department of Allergy and Immunology, Wilford Hall Medical Center, San Antonio, Texas, U.S.A. jlarochelle@usuhs.mil
Background:
Resistin is a protein produced by adipocytes and circulating macrophages that has been found to be associated with inflammatory states.
Objective:
To determine the levels of resistin in relation to asthma disease state and severity, we investigated a cohort of adult patients with asthma.
Methods:
A cohort of moderate to severe persistent asthma patients and control patients were recruited and underwent fasting labs to evaluate levels of serum glucose, C-reactive protein (CRP), and resistin.
Results:
No significant differences were found between the control and asthma group with respect to serum CRP at 0.78 +/- 0.60 mg/dL and 0.48 +/- 0.60 mg/dL, (p < 0.36) or glucose at 92.2 +/- 11.9 mg/dL and 89.5 +/- 7.2 mg/dL, (p < 0.084), respectively (mean +/- SD). However, plasma resistin levels were found to be significantly elevated in asthma patients, 186 ng/mL (95%CI 169-202) compared with control patients 121 ng/mL (95%CI 90.4-151), (p < 0.005).
Conclusions:
Patients with asthma were found to have higher levels of resistin, and resistin levels were increased with disease severity in the asthma cohort.
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