[Brugada syndrome and work place: two case report]

Area of Science:

• Cardiology
• Genetics
• Electrophysiology

Background:

• Brugada Syndrome (BS) is a primary electrical heart disease leading to sudden cardiac death and ventricular arrhythmias.
• It is an inherited condition with an autosomal dominant transmission pattern, often linked to SCN5A gene mutations affecting cardiac sodium channels.

Observation:

• Characteristic electrocardiogram (ECG) findings include ST-segment elevation in right precordial leads, which can be intermittent or unmasked by antiarrhythmic drugs.
• Two cases of probable BS were observed in workers exposed to occupational risks, highlighting potential environmental influences.

Findings:

• BS accounts for a significant percentage (4-50%) of sudden cardiac deaths.
• Untreated BS carries a poor prognosis, with a high recurrence rate of ventricular tachycardia in affected individuals.

Implications:

• The study underscores the importance of cardiac surveillance and examination for early detection of patients at risk for ventricular arrhythmogenic events.
• Occupational risk assessment should consider cardiac health, particularly in individuals with potential BS risk factors.