Biocompatible microemulsions and their prospective uses in drug delivery

Efficacy of lipophilic drugs is often hindered due to their poor aqueous solubility leading to low absorption after in vivo administration. A part of the administered dose is absorbed and reaches the pharmacological site of action and the remainder causes toxicity and undesirable side effects due to unwanted biodistribution. Enhancement in drug efficacy and lowering of drug toxicity could be achieved through encapsulation and delivery of the lipophilic drugs in aqueous based delivery systems. Microemulsions are macroscopically homogeneous pseudoternary and ternary colloidal assemblies having polar and nonpolar micro domains. Their dispersed phases in nanodimension have good shelf-life (due to thermodynamic stability), large surface area, low viscosity (in some compositions), and ultraslow surface tension. These properties qualify them to be prospective drug delivery systems provided they are composed of biocompatible excipients. Due to the existence of polar, nonpolar, and interfacial microdomains, encapsulation of different kinds of drugs is possible. The review entails reports on development and characterization of biocompatible microemulsion systems and their evaluation as probable vehicles for encapsulation, stabilization, and delivery of bioactive natural products and prescription drugs.