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Updated: Jul 11, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Applications of multicomponent reactions for the synthesis of diverse heterocyclic scaffolds
James D Sunderhaus1, Chris Dockendorff, Stephen F Martin
1Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin Texas 78712, USA.
Abstract:
A four-component coupling process involving sequential reactions of aldehydes, primary amines, acid chlorides, and nucleophiles has been developed to prepare multifunctional substrates that may be employed in subsequent ring-forming reactions to generate a diverse array of functionalized heterocyclic scaffolds. This new approach to diversity-oriented synthesis was then applied to the first total synthesis of the isopavine alkaloid (+/-)-roelactamine.
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