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Macrolactins O-R, glycosylated 24-membered lactones from Bacillus sp. AH159-1
Chang-Ji Zheng1, Sangku Lee, Choong-Hwan Lee
1Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon 305-806, Republic of Korea.
Abstract:
In the course of screening for inhibitors of Staphylococcus aureus peptide deformylase, four new glycosylated macrolactin compounds, macrolactins O ( 1), P ( 2), Q ( 3), and R ( 4), along with the known macrolactins B ( 5) and C ( 6), have been isolated from the liquid cultures of Bacillus sp. AH159-1. The structures of compounds 1- 4 were assigned on the basis of MS and NMR data. They inhibited S. aureus peptide deformylase and also showed antibacterial activity against Escherichia coli and Staphylococcus aureus.
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