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Related Experiment Video

Updated: Jul 11, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Circulating RANKL/OPG in polymyalgia rheumatica.

L Pulsatelli1, P Dolzani, T Silvestri

  • 1Laboratorio di Immunologia e Genetica, Istituti Ortopedici Rizzoli, Bologna, Italy.

Clinical and Experimental Rheumatology
|September 25, 2007
PubMed
Summary

Polymyalgia rheumatica (PMR) patients show increased levels of soluble RANKL (sRANKL), a protein linked to bone loss. Corticosteroid treatment did not alter these elevated sRANKL levels in active disease.

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Last Updated: Jul 11, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Area of Science:

  • Rheumatology
  • Endocrinology
  • Bone Biology

Background:

  • Polymyalgia rheumatica (PMR) is an inflammatory condition often associated with osteoporosis.
  • The RANK/RANKL/OPG system plays a critical role in bone remodeling and is implicated in various bone diseases.

Purpose of the Study:

  • To investigate the RANKL/OPG balance in patients with polymyalgia rheumatica (PMR).
  • To determine if this balance is altered during active disease or corticosteroid treatment.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of RANKL and OPG.
  • Measurements were taken in PMR patients with active untreated disease and during a 12-month follow-up of corticosteroid treatment.
  • Comparison was made with healthy controls.

Main Results:

  • No significant difference in OPG levels was observed between PMR patients and controls.
  • Systemic production of soluble RANKL (sRANKL) was found to be elevated in PMR patients.
  • Corticosteroid treatment did not modulate the increased sRANKL levels.

Conclusions:

  • Elevated sRANKL levels in PMR may contribute to the pathogenesis of osteoporosis in these patients.
  • Further research is needed to elucidate the precise role of the RANK/RANKL/OPG system in bone turnover in PMR.