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Related Experiment Videos

Phospholipase C-sensitive factor VII complexes in dog plasma.

H Prydz1, N W Spurling, A J Boyce

  • 1Research Institute for Internal Medicine, and Biotechnology, University of Oslo.

Thrombosis Research
|November 15, 1991
PubMed
Summary

A special diet activates a factor VII complex in dog plasma, with levels varying significantly between individual dogs. This complex was found at low levels when dogs were fasting.

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Area of Science:

  • Hemostasis and thrombosis research
  • Canine physiology and nutrition

Background:

  • Factor VII is a key protein in the blood coagulation cascade.
  • Dietary intake can influence hemostatic factors in various species.

Purpose of the Study:

  • To investigate the effect of a specific diet on activated Factor VII complex levels in canine plasma.
  • To assess the variability in response to dietary changes among individual dogs.

Main Methods:

  • Analysis of canine plasma samples.
  • Measurement of phospholipase C-sensitive activated Factor VII complex.
  • Comparison of complex levels in fed versus fasting states.

Main Results:

  • A phospholipase C-sensitive activated Factor VII complex was detected in canine plasma post-feeding.

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  • Significantly lower levels of the complex were observed in the fasting state.
  • Marked inter-dog variability in the response of activated Factor VII to feeding was noted.

    • Conclusions:

    • Dietary intake can modulate the presence and levels of activated Factor VII complex in dogs.
    • Individual canine responses to dietary factors influencing coagulation are highly variable.