Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid lipid nanoparticles prepared by solvent diffusion method in a nanoreactor system.

Hong Yuan1, Ling-Fei Huang, Yong-Zhong Du

  • 1College of Pharmaceutical Science, Zhejiang University, 388 Yuhangtang Road, Hangzhou 310058, PR China. yuanghong70@zju.edu.cn

Colloids and Surfaces. B, Biointerfaces
|September 25, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: A novel biocompatible, simvastatin-loaded, bone-targeting lipid nanocarrier for treating osteoporosis more effectively.

RSC advances·2022
Same author

A novel biocompatible, simvastatin-loaded, bone-targeting lipid nanocarrier for treating osteoporosis more effectively.

RSC advances·2022
Same author

Near-Infrared Responsive Membrane Nanovesicles Amplify Homologous Targeting Delivery of Anti-PD Immunotherapy against Metastatic Tumors.

Advanced healthcare materials·2021
Same author

Thermal-sensitive lipid nanoparticles potentiate anti-PD therapy through enhancing drug penetration and T lymphocytes infiltration in metastatic tumor.

Cancer letters·2021
Same author

Quercetin Covalently Linked Lipid Nanoparticles: Multifaceted Killing Effect on Tumor Cells.

ACS omega·2020
Same author

Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment.

Journal of Zhejiang University. Science. B·2020

This study developed solid lipid nanoparticles (SLN) using a water-in-oil miniemulsion nanoreactor. The novel method yielded smaller SLN with higher drug entrapment efficiency compared to conventional techniques.

Area of Science:

  • Pharmaceutical Nanotechnology
  • Materials Science
  • Drug Delivery Systems

Background:

  • Solid lipid nanoparticles (SLN) offer advantages for drug delivery.
  • Conventional methods for SLN preparation can be improved for efficiency.
  • Miniemulsions serve as effective nanoreactors for nanoparticle synthesis.

Purpose of the Study:

  • To prepare solid lipid nanoparticles (SLN) using a water-in-oil (W/O) miniemulsion as a nanoreactor.
  • To compare the physicochemical properties and drug release of SLN prepared by a novel solvent diffusion method with a conventional method.
  • To investigate the effect of drug loading on SLN properties and release profile.

Main Methods:

  • Preparation of stable W/O miniemulsion using n-hexane, Tween 80, and Span 80.

Related Experiment Videos

  • Synthesis of SLN via solvent diffusion within the miniemulsion nanoreactor.
  • Characterization of SLN including particle size, zeta potential, morphology, entrapment efficiency, drug loading, and in vitro drug release of Clobetasol propionate (CP).

    • Main Results:

    • A stable W/O miniemulsion (27.1+/-7.6 nm) was achieved with a specific composition.
    • SLN prepared by the novel method exhibited smaller particle size and higher drug entrapment efficiency than conventional SLN.
    • A drug loading of 15.9% was achieved with 20% drug charge; drug content did not affect release rate.

    Conclusions:

    • The W/O miniemulsion is an effective nanoreactor for preparing SLN with enhanced properties.
    • The novel solvent diffusion method offers advantages over conventional techniques for SLN production.
    • The developed SLN demonstrate potential for efficient drug delivery with controlled release characteristics.