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Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes

Martijn Verdoes1, Ulrik Hillaert, Bogdan I Florea

  • 1Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.

Bioorganic & Medicinal Chemistry Letters
|September 25, 2007
PubMed

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Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...