Related Experiment Video
Updated: Jul 11, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Neonatal tolerance and patent filarial infection
1Department of Pathology, 263 Farmington Avenue, Farmington, CT 06032, USA. rajan@neuron.uchc.edu
Abstract:
Lymphatic filariasis occurs in endemic pockets. Patent infections with long-term, high-grade microfilaremia do not develop in nonendemic individuals. It is tempting to speculate that individuals with intact immune responses to filarial antigens are capable of dealing with filarial exposure without developing persistent infection. There are published data that support the idea that only those individuals who are impaired in their immune defense against these parasites owing to neonatal tolerization become productively infected with the filarial parasites. If the model is correct, there are profound implications for global eradication.
More Related Videos
Related Concept Videos
Anthelminthic Agents
Malaria
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Antiprotozoal Agents
Pharmacokinetics in Pediatric Patients: Drug Excretion

