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Related Experiment Video

Updated: Jul 11, 2026

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

Published on: July 15, 2021

Thirty-day in-parallel artificial lung testing in sheep.

Hitoshi Sato¹, Candice M Hall, Nathan G Lafayette

¹Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

The Annals of Thoracic Surgery

|September 25, 2007

Summary

The MC3 Biolung total artificial lung (TAL) demonstrated feasibility for 30-day respiratory support in sheep. Further research is needed to improve biocompatibility and reduce device thrombogenicity.

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Area of Science:

Biomedical Engineering
Cardiovascular Research
Respiratory Support Devices

Background:

The MC3 Biolung total artificial lung (TAL) underwent 30-day testing in preparation for clinical trials.
This study evaluated the performance and safety of the TAL in a preclinical ovine model.

Purpose of the Study:

To assess the feasibility and performance of the MC3 Biolung total artificial lung (TAL) for extended respiratory support.
To identify potential areas for improvement in device biocompatibility and anticoagulation strategies.

Main Methods:

The TAL was implanted in 8 sheep, with hemodynamic and blood gas parameters monitored regularly.
Device performance was assessed by monitoring resistance and oxygen transfer, with replacement criteria defined.
Organ function and post-mortem findings were evaluated after 30 days or premature euthanasia.

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Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

Related Experiment Videos

Last Updated: Jul 11, 2026

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

Published on: July 15, 2021

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

Main Results:

Five of eight sheep survived the 30-day study period, with survivors exhibiting stable hemodynamics and blood gases.
The TAL demonstrated consistent oxygen transfer and acceptable resistance levels throughout the study.
Increased platelet and white blood cell counts were observed, with mild ischemic kidney lesions noted at necropsy.

Conclusions:

Thirty-day respiratory support using the MC3 Biolung TAL is feasible in an ovine model.
Improvements in biocompatibility and anticoagulation are necessary to mitigate device-related thrombogenicity.