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Cardioplegia and diazoxide modulate STAT3 activation and DNA binding

Yng-Ju Hsieh1, Hidetaka Wakiyama, Sidney Levitsky

  • 1Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA.

The Annals of Thoracic Surgery
|September 25, 2007
PubMed
Summary

Diazoxide addition to cardioplegia significantly reduces heart cell death after ischemia by enhancing STAT3 signaling. This improves myocardial protection during cardiac surgery.

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